A naturally occurring opioid peptide from cow's milk, beta-casomorphine-7, is a direct histamine releaser in man.
Kurek M, Przybilla B, Hermann K, Ring J.
SourceDepartment of Dermatology, Ludwig-Maximilian-University, Munich.
http://www.ncb...i.nlm.nih.gov/pubmed/1374738
Abstract
beta-Casomorphine-7, a naturally occurring product of cow's milk with opiate-like activity, was studied for possible direct histamine liberation activities in humans. It was found to cause concentration-dependent in vitro histamine release from peripheral leukocytes of healthy adult volunteers. Intradermal injection of beta-casomorphine-7 induced a wheal and flare reaction in the skin similar to histamine or codeine. Oral pretreatment with the H1 antagonist terfenadine significantly inhibited the skin responses to beta-casomorphine-7. The intradermal injection of an opiate receptor antagonist, naloxone, inhibited in vitro histamine release and skin reactions only in a 100-fold excess over beta-casomorphine-7. These findings suggest that beta-casomorphine-7 can be regarded as a noncytotoxic, direct histamine releaser in humans. The clinical relevance of these findings deserves further studies.
PMID:1374738[PubMed - indexed for MEDLINE
Kurek M, Przybilla B, Hermann K, Ring J.
SourceDepartment of Dermatology, Ludwig-Maximilian-University, Munich.
http://www.ncb...i.nlm.nih.gov/pubmed/1374738
Abstract
beta-Casomorphine-7, a naturally occurring product of cow's milk with opiate-like activity, was studied for possible direct histamine liberation activities in humans. It was found to cause concentration-dependent in vitro histamine release from peripheral leukocytes of healthy adult volunteers. Intradermal injection of beta-casomorphine-7 induced a wheal and flare reaction in the skin similar to histamine or codeine. Oral pretreatment with the H1 antagonist terfenadine significantly inhibited the skin responses to beta-casomorphine-7. The intradermal injection of an opiate receptor antagonist, naloxone, inhibited in vitro histamine release and skin reactions only in a 100-fold excess over beta-casomorphine-7. These findings suggest that beta-casomorphine-7 can be regarded as a noncytotoxic, direct histamine releaser in humans. The clinical relevance of these findings deserves further studies.
PMID:1374738[PubMed - indexed for MEDLINE
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